The role of NPY in expression and extinction of conditioned fear
نویسندگان
چکیده
Background Neuropeptide Y is a highly conserved 36 amino acid peptide that is widely distributed in the peripheral and central nervous systems. Besides its functions in various metabolic processes, NPY has attracted considerable attention in modulating emotional-affective behavior. NPY exerts a solid anxiolytic effect most likely mediated by Y1 receptors, whereas stimulation of predominantly pre-synaptic Y2 receptors results in increased anxiety. However, little is known about an involvement of NPY in processing of fear.
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The role of neuropeptide Y in the expression and extinction of fear-potentiated startle.
Neuropeptides are a promising target for novel treatments for anxiety and other psychiatric disorders and neuropeptide Y (NPY) has emerged as a key component of anxiolytic circuits in the brain. For this reason, we have evaluated the role of NPY in the expression and extinction of conditioned fear. We found that intracerebroventricular administration of NPY inhibits both baseline acoustic start...
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